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We perform a variety of meta-analyses for academic, regulatory, and international clients. Each presents a different set of challenges regarding study design and outcome measurement. We have found CMA to be invaluable in this work. The ability of the software to capture a variety of data elements (study design, multiple outcomes, covariates/confounders) and present details of computations is important in the credibility of our work. The ease of use and ability to produce graphics in a variety of formats aids in preparation of the report. In many instances, we are required to replicate the results of CMA in another package (e.g., SAS). We have always found the support staff at CMA very helpful in these replications and the results of CMA have been replicated in every instance. CMA is a great tool in the scientific credibility of our meta-analytic studies.